Endocrine Abstracts

Context: There is scant evidence of tumoral mass reduction in Thyrotropin-secreting pituitary adenomas (TSPA) treated with long-acting somatostatin analogs. There are no reports that evaluate TSPA shrinkage after deep subcutaneous (sc) Lanreotide-ATG (L-ATG) therapy.Objective: The primary objective was to observe if L-ATG could reduce TSPA tumor mass.Methods: A literature review on the subject was made. The biochemical and radiolog...

Background: Type 2 DM and chronic renal disease CKD are conditions associated with severe hypertension, loss of the blood pressure circadian rhythm (CR) and sympathetic nervous system (SNS) hyperactivity, suggesting a deficient dopaminergic modulation that could be reversed with dopamine agonists such as bromocriptine (BEC).Objective: The objective of this study was to evaluate the effect of bromocriptine in the blood pressure CR in patients with type 2 ...

Objective: Combination with cabergoline may offer additional benefits to acromegalic patients on pegvisomant monotherapy. We evaluated the safety and efficacy profile of this combination and investigated the determinants of response.Design: An observational, retrospective, cross-sectional, registry-based study.Patients and methods: Fourteen acromegalic patients (9 females), who were partially resistant to somatostatin analogs and o...

Introduction: Modifications of gut microbiota have been described in relation to inflammatory bowel disease (IBD), dietary habits and nutritional status.Objective: To relate gut microbial pattern of patients with IBD compared to healthy individuals; and link gut microbial pattern with activity of the disease, nutritional status and dietary habit.Material and methods: Observational study of 56 subjects (44 with IBD and 12 controls)....